Each COBRE must be advised by an EAC comprised of 3-5 scientists with national scientific reputations in their fields. Their expertise must be directly relevant to the scientific theme of the COBRE. The EAC critiques the scientific progress of the COBRE and also offers advice on scientific matters to the COBRE PD(s)/PI(s). The EAC is involved in developing and planning concepts and programs, encouraging and assisting faculty development and career guidance, identifying resources, evaluating the development of the center, evaluating the progress of the individual research projects, and evaluating the junior investigators' progress toward acquiring independent status. The PD(s)/PI(s) share the advice and critiques provided by the EAC with other COBRE investigators at the center. The EAC also reviews and recommends candidate investigators for replacement/substitute projects, as required, before such requests are forwarded to the NIGMS for programmatic review. The following individuals are members of the External Advisory Board of the Center for Molecular Medicine's cores:
Ralph Bradshaw, Ph.D.
University of California at San Francisco
Dr. Bradshaw is Professor in the Department of Pharmaceutical Chemistry at the University of San Fancisco. He is widely recognized for his pioneering studies of nerve growth factor and nerve growth factor receptor structure and function. In addition he is a noted protein chemist and a leader in the development of proteomics. He is the past chair of Biochemistry at UC Irvine and is currently Editor-in-chief of Molecular and Cellular Proteomics, a journal that he initiated for ASBMB.
David Nanus, M.D.
Weill Medical College of Cornell University
Dr. Nanus is a urologic oncologist well known for his studies of the effects of cell-surface peptidases and the regulation of their expression by steroids in the development and progression of prostate cancer and renal cancer. He is currently the Chief, Division of Hematology and Medical Oncology, Department of Medicine.
J. Thomas Parsons, Ph.D.
Professor of Microbiology at the University of Virginia
Dr. Parsons is highly recognized for his outstanding work on tyrosine kinases associated with focal adhesions and their role in cell adherence, cell migration, cell division and transformation. Dr. Parsons is the previous chair of the Department of Microbiology at the University of Virginia.
Doug Rees, Ph.D.
California Institute of Technology
Dr. Rees is an HHMI investigator and a member of the National Academy of Sciences. He is well known for his major contributions to the structural biology of proteins involved in biological energy transduction processes. He has particularly focused on metalloproteins and membrane transporters.
H. Ronald Kaback, M.D.
David Geffen School of Medicine at UCLA
Dr. Kaback is known for his pioneering work on active transport of molecules across cell membranes and the development of isolated vesicles for studying membrane transport, known as Kabackosomes. He is an elected member of the National Academy of Sciences.
Although the individual career development of the junior investigators is an important part of this program, the primary objective of the COBRE initiative is to build and develop thematic multi-disciplinary research centers. This is accomplished through the leadership of a peer-reviewed, funded investigator with expertise central to the research theme of the application. The scientific leadership provided by one or more established biomedical research faculty is critical to the success of this FOA, especially for the career guidance of promising junior investigators. The following professors look over the cores of the Center for Molecular Medicine:
Dr. Doug Andres
Professor and Chair of the Department of Biochemistry
Dr. James Geddes
Professor and Head of the Spinal Cord and Brain Injury Research Center
Dr. Michael Mendenhall
Associate Professor and Genetic Technologies Core Director
Dr. Craig Rush
Professor and Associate Vice President of Research
Dr. David Watt
Professor and Organic Synthesis Core Director
Dr. Trevor Creamer
Professor and Associate Director for Center for Structural Biology